Measurement of inter-proton distances from cross-relaxation rates determined by a selective null inversion–recovery NMR method
✍ Scribed by Maili Liu; R. Duncan Farrant; John C. Lindon
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 312 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0749-1581
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✦ Synopsis
Abstract
An efficient method of measuring proton spin–lattice cross‐relaxation rates in small molecules is proposed. The method involves measuring the difference in relaxation rates in a non‐selective experiment and in one with all resonances except one of interest inverted. This procedure yields cross‐relaxation rates between this nucleus and all other nuclei. These rates are independent of the effects of non‐excited heteronuclei and of non‐dipolar contributions and can be used to determine relative inter‐proton distances. The method was tested using 7‐azaindole and compared favourably with the standard NOE method for estimating proton proximities requiring less data acquisition time.