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Measurement of glycine in human prefrontal brain by point-resolved spectroscopy at 7.0 tesla in vivo

✍ Scribed by Changho Choi; Deborah Douglas; Halima Hawesa; Ashish Jindal; Charles Storey; Ivan Dimitrov

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
516 KB
Volume
62
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Measurement of glycine in human frontal brain by an optimized point‐resolved spectroscopy sequence at 7 T is reported. Echo time dependencies of the overlapping coupled resonances of myo‐inositol, free choline, and threonine were investigated with density matrix simulations, incorporating the slice‐selective radiofrequency and gradient pulses. The numerical simulations indicated that the selectivity of the 3.55‐ppm glycine singlet is maximized at (TE~1~, TE~2~) = (101, 51) ms. Phantom experiments indicated that the myo‐inositol peak amplitude between 3.5 and 3.6 ppm is reduced by a factor of 30 following the optimized point‐resolved spectroscopy, as predicted by the simulation. From LCModel analyses, the glycine concentration in the medial prefrontal cortex in healthy adults was estimated, with a mean Cramér‐Rao lower bound of 7 ± 1% (mean ± standard deviation; n = 7), to be 0.8 ± 0.1 mM, with reference to total creatine at 8 mM. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.

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