Measurement of extracellular volume fraction by cardiac magnetic resonance imaging detects diffuse myocardial fibrosis in systemic sclerosis

✍ Scribed by Daniel C Lee; Roberto Sarnari; Alejandro Aquino; Maria M Izquierdo-Gomez; Brandon Benefield; Monique Hinchcliff; John Varga; Sofia Podlusky; Maria Carr; Aya Kino; James Carr; Edwin Wu; Sanjiv Shah

• Book ID: 104499091
• Publisher: BioMed Central
• Year: 2012
• Tongue: English
• Weight: 114 KB
• Volume: 14
• Category: Article
• ISSN: 1097-6647
• DOI: 10.1186/1532-429x-14-s1-o28

✦ Synopsis

We measured extracellular volume fraction (Ve) from pre-and post-contrast T1 maps of the left ventricle in 13 patients with systemic sclerosis (SSc) and 13 agematched controls. SSc patients and controls were similar with regard to LV and RV mass, volumes, and function. However, Ve was significantly higher in SSc patients than in controls, even when patients with visible late gadolinium enhancement were excluded. Ve correlated with SSc severity as measured by the modified Rodnan Skin Score. Ve may be valuable for detection of myocardial involvement in SSc, even when conventional CMR appears normal.