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Measurement of dissociation constants (pKa values) of organic compounds by multiplexed capillary electrophoresis using aqueous and cosolvent buffers

โœ Scribed by Shalaeva, Marina (author);Kenseth, Jeremy (author);Lombardo, Franco (author);Bastin, Andrea (author)

Publisher
John Wiley and Sons Inc.
Year
2008
Tongue
English
Weight
458 KB
Volume
97
Category
Article
ISSN
0022-3549

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๐Ÿ“œ SIMILAR VOLUMES

Measurement of dissociation constants (p
Measurement of dissociation constants (pKa values) of organic compounds by multiplexed capillary electrophoresis using aqueous and cosolvent buffers
โœ Marina Shalaeva; Jeremy Kenseth; Franco Lombardo; Andrea Bastin ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 458 KB

Evaluation of a multiplexed capillary electrophoresis (CE) method for pK(a) measurements of organic compounds, including low solubility compounds, is presented. The method is validated on a set of 105 diverse compounds, mostly drugs, and results are compared to literature values obtained from multip