Measurement of cytokine production by the monocytic cell line mono mac 6 using novel immunoradiometric assays for interleukin-1β and interleukin-6

A NOVEL AND RAPID PREDICTION ASSAY FOR T

A NOVEL AND RAPID PREDICTION ASSAY FOR THE EFFECTIVENESS OF IL-6 RECEPTOR SPECIFIC ANTISENSE OLIGONUCLEOTIDES BY PROLIFERATION INHIBITION OF AN INTERLEUKIN-6 DEPENDENT CELL LINE

✍ Valeria Lia Varga; Andras Falus; Eva Pallinger; István Novák; Kristóf A. Fülöp; 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 123 KB

Interleukin-6 (IL-6) belongs to a family of cytokines that use receptors consisting of a common signal-transducing chain (gp130). Baf/3 cells transfected with the human IL-6 receptor (IL-6R) and gp130 (Baf/3-gp130/IL-6R) can only grow in medium containing IL-6. We attempted to interrupt the signal t