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Measurement of Carvedilol Enantiomers in Human Plasma and Urine Using S-Naproxen Chloride for Chiral Derivatization

✍ Scribed by Hildegard Spahn; Werner Henke; Peter Langguth; Jürgen Schloos; Ernst Mutschler


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
432 KB
Volume
323
Category
Article
ISSN
0365-6233

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## Abstract An enantioselective high‐performance liquid chromatographic method for the analysis of carvedilol in plasma and urine was developed and validated using (‐)‐menthyl chloroformate (MCF) as a derivatizing reagent. Chloroform was used for extraction, and analysis was performed by HPLC on a