## Abstract Infection and reinfection of infants with human respiratory syncytial virus (HRSV) occur despite the presence of serum anti‐viral glycoprotein antibodies similar to those, which afford protection in animal models of infection. Antigenic variation of the viral glycoproteins between diffe
Measurement of antibody against contemporary virus lineages of human respiratory syncytial virus sub-group A in infants and their mothers
✍ Scribed by A McGill; J Greensill; A.W Craft; F Fenwick; G.L Toms
- Book ID
- 116630555
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 99 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1386-6532
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The fusion glycoprotein, F, of human respiratory syncytial virus is a principal target of neutralising antibodies and an important protective immunogen. Among sub-group A strains of the virus the F gene is highly conserved. A comparison of F gene sequences of two sub-group B strains, 8/60 and 18537,
## Abstract Antibodies directed against human respiratory syncytial virus (HRSV) glycoproteins were depleted from a commercial immunoglobulin preparation (RespiGam) by two different methods. The first method consisted of repeated adsorption of RespiGam to Sepharose beads with covalently bound solub