Measurement of anti-dsdna
✍ Scribed by Charles R Steinman
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 213 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0004-3591
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Analysis of somatic mutations revealed that induction of anti-dsDNA autoantibodies from SLE patients are antigen driven and thus T cell dependent. Since DNA per se has repeatedly been shown not to be immunogenic, various mechanisms leading to the production of anti-dsDNA-antibodies have been discuss
## Abstract The measurement of antibodies to double‐stranded DNA (anti‐dsDNA) is a useful tool for the diagnosis and monitoring of patients with connective tissue diseases, particularly systemic lupus erythematosus (SLE). The aim of the present study was to compare a new enzyme‐linked immunosorbent
Antibodies to DNA are quite specific for systemic lupus erythematosus (SLE) and occur in the majority of SLE patients. Therefore, their detection is an important diagnostic aid to the clinician. Detection of anti-dsDNA may precede the diagnosis of SLE by more than a year. Fluctuations in the level o