Mean platelet volume is increased in hyperthyroidism

✍ Scribed by Dr. H. C. Ford; R. J. Toomath; J. M. Carter; J. W. Delahunt; J. N. Fagerstrom

• Book ID: 101436764
• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 292 KB
• Volume: 27
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/ajh.2830270308

✦ Synopsis

In 28 unselected patients with hyperthyroidism, platelet count, platelet hematocrlt, mean platelet volume, and platelet distribution width were measured at the time of presentation and agaln when the patients were euthyrold. On return to the euthyrold state, there were hlghly significant falls In the mean values of the mean platelet volume (16% decline, P < 0,001) and the platelet hematocrit (16% decline, P < 0.001) and a slight but hlghly significant increase In the mean value of the platelet distribution width (2% Increase, P < 0.01). A decline In mean platelet volume was observed In 24 of 28 patients (86%); three patlents showed no change. There was no significant change In the mean value of the platelet count. The observed effects of thyrotoxicosls on platelets appeared to be largely Independent of the well-known effects on erythrocytes and white blood cells. An Increase In mean platelet volume I s a regular feature of hyperthyroidism that has not previously been described.