𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Mean first-passage time in the steady-state kinetics of biochemical processes

✍ Scribed by P. CheŁminiak; M. Kurzyn´ski

Book ID
104304118
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
336 KB
Volume
86
Category
Article
ISSN
0167-7322

No coin nor oath required. For personal study only.

✦ Synopsis

The Hill's technique of snmming up the directional diagrams has been developed in order to calculate the steady-state operational fluxes for a single and two coupled enzymatic reactions controlled and gated by the arbitrary type stochastic dyDamics of conformational transitions of the protein enzyme involved. It is shown that these fluxes cannot be described in terms of the complete rate constants of the component reactions but, separately, by the equilibrium (transition state theory) contributions to the rate constants and the mean first-passage times between the succeeding gates.

📜 SIMILAR VOLUMES

Lifetime of metastable states: The mean
Lifetime of metastable states: The mean first passage time and a generalized Kramers method
✍ Dietrich Ryter 📂 Article 📅 1985 🏛 Elsevier Science 🌐 English ⚖ 729 KB

The method of Kramers is generalized for arbitrary (Markovian and continuous) metastable systems with isolated transition points. The result for the transition rate is shown to coincide with that obtained from the mean first passage time. This second method, which holds for more general sets of tran