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Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42

✍ Scribed by Marco Duering; Marcus O.W. Grimm; Heike S. Grimm; Johannes Schröder; Tobias Hartmann


Book ID
116780559
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
152 KB
Volume
26
Category
Article
ISSN
0197-4580

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## Communicated by Mark Paalman The varied ways in which mutations in presenilins (PSEN1 and PSEN2) affect amyloid b precursor protein (APP) processing in causing early-onset familial Alzheimer disease (FAD) are complex and not yet properly understood. Nonetheless, one useful diagnostic marker is a