Mean 24-hour growth hormone and testosterone concentrations in relation to pubertal growth spurt in boys with normal or delayed puberty

✍ Scribed by O. Butenandt; R. Eder; K. Wohlfarth; F. Bidlingmaier; D. Knorr

• Publisher: Springer
• Year: 1976
• Tongue: English
• Weight: 417 KB
• Volume: 122
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00466266

✦ Synopsis

The mean growth hormone concentration during a 24-hour period in 7 boys of short familial stature and a growth rate of 3.2--5.4 era/year was between 1.0 and 4.6 ng/ml serum. In 7 boys with pubertal growth spurt and familial tallness (growth rate 7.2--11.0 cm/ year) it varied from 0.97 to 4.4 ng/ml and in 6 boys with constitutional delay of puberty (a growth rate of 4.2--5.2 era/year prior to puberty) from 1.3 to 4.3 ng/ml.

No correlation was found between the 24-hour mean growth hormone concentration and the mean 24-hour testosterone concentration in serum or the growth rate, but a correlation was found between testosterone and the growth rate.

It is concluded that the growth spurt in puberty is not due to a change in growth hormone concentration but rather to the increase of androgen production in puberty.