‘Me2CuLi·TMSCl in CH2Cl2’. The most powerful methylating agent for sterically congested α,β-enoates

✍ Scribed by Naoki Asao; Sunyoung Lee; Yoshinori Yamamoto

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 162 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)00891-8

✦ Synopsis

The reaction of Me 2 CuLi with sterically congested a,b-unsaturated esters in the presence of TMSCl in CH 2 Cl 2 proceeded very smoothly to produce the conjugate addition products in high yields.