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MDS and AML with 17p deletion are associated to specific dysgranulopoiesis and a high incidence of p53 mutations

✍ Scribed by C. Preudhomme; J.L. Lai; M. Zandecki; M. Vanrumbeke; M. Flactif; E. Wattel; P. Fenaux


Book ID
113239964
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
99 KB
Volume
18
Category
Article
ISSN
0145-2126

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## Abstract A series of 121 human breast tumors was screened for point mutations in exons 5 through 8 of the p53 gene, by SSCP analysis. On the same tumor samples, the S‐phase index (SPI) was determined by the incorporation of BUdR in fresh tissue. p53 mutations were observed in 29% of the cases. T