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MDR- and CYP3A4-Mediated Drug–Drug Interactions

✍ Scribed by Pal, Dhananjay; Mitra, Ashim K.

Book ID
107380566
Publisher
Springer US
Year
2006
Tongue
English
Weight
481 KB
Volume
1
Category
Article
ISSN
1557-1890

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✍ Helena A. Engman; Hans Lennernäs; Jan Taipalensuu; Charlotta Otter; Brith Leidvi 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 251 KB

The aim of this study was to ®nd a cell culture model of the intestinal epithelium for use in studies of CYP3A4-mediated ®rst-pass metabolism of drugs and also for studies of the interplay between CYP3A4 metabolism and P-glycoprotein ef¯ux. For this purpose, the expression of CYP3A4, CYP3A5, and MDR