Investigation of an NQO1 polymorphism as
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Asher Begleiter; Donna Hewitt; Spencer B. Gibson; James B. Johnston
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Article
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2009
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Elsevier Science
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English
⚖ 395 KB
NAD(P)H:quinoneoxidoreductase 1 (NQO1) inhibits some cancers and increases p53 and apoptosis in cells. Due to an inactivating polymorphism, 10% of humans have no NQO1 activity. A case:control study suggested that chronic lymphocytic leukemia (CLL) patients may have an increased incidence of the NQO1