MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF

EGF stimulates anchorage-independent gro

EGF stimulates anchorage-independent growth of a human bladder carcinoma cell line (KU1) with an amplified and over-expressed EGF receptor gene

✍ Jiro Ishikawa; Sakan Maeda; Taketoshi Sugiyama; Ryuichiro Nishimura; Akira Mizog 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 695 KB

Southern blot analysis of 6 human bladder carcinoma cell lines revealed amplification of the epidermal growth factor receptor (EGFR) gene in the KUI cell line. The amplification of the gene was about 4-fold as compared with that of human placental DNA. Several restriction endonuclease digestions rev