Small cell lung cancer (SCLC) cell lines and tumors invariably exhibit loss of heterozygosity (LOH) or, in rare cases, homozygous deletions involving part or all of chromosome arm 3p, suggesting the presence of 1 or more tumor-suppressor genes in this region. The gene encoding aminoacylase-1 (ACY1)
Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines
โ Scribed by Zhang, H; Guttikonda, S; Roberts, L; Uziel, T; Semizarov, D; Elmore, S W; Leverson, J D; Lam, L T
- Book ID
- 109972681
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 412 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
We have reported the establishment of a mitomycin-C (MMC)resistant non-small-cell lung-cancer cell line, PC-9/MC4. As determined by an MlT assay, this resistant cell line was found to be 4 times more sensitive to adriamycin (ADM) than was the parental PC-9. There were no significant differences in s
Docetaxel (DOC), a member of the taxane family of anticancer drugs, binds to tubulin and produces unnaturally stable microtubules that induce cell death. DOC is used clinically alone or in combination with other compounds to treat advanced stages of cancer. We have treated the human lung cancer cell