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McDiarmid HM, Douglas GR, Coomber BL, Josephy PD. 2002. 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mutagenesis in cultured Big BlueTM rat mammary epithelial and fibroblast cells. Environ Mol Mutagen 39:245–253.

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 25 KB
Volume: 40
Category: Article
ISSN: 0893-6692
DOI: 10.1002/em.10091

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✦ Synopsis

In the footnote to Table III, the units for glutathione-S-transferase activity were reported as pmol substrate conjugated/ min/mg protein. This should have been nmol, not pmol. The corrected version of Table III is given below.

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2-Amino-1-methyl-6-phenylimidazo[4,5-b]p

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)–induced mutagenesis in cultured Big Blue™ rat mammary epithelial and fibroblast cells

✍ Heather M. McDiarmid; George R. Douglas; Brenda L. Coomber; P. David Josephy 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 184 KB

## Abstract Epithelial cells are the primary site of carcinogenesis in most tissues, including the mammary gland. As an alternative to the study of mutation induction in whole tissues in vivo, we have established Big Blue™ transgenic rat cell lines from the mammary epithelium (BBR/ME) and the mamma