McArdle's disease and gout

✍ Scribed by Dr. Juan G. Puig; Dr. Eugenio de Miguel; Dr. Felícitas A. Mateos; Dr. Ma Eugenia Miranda; Dr. Nuria M. Romera; Dr. Ana Espinosa; Dr. Juan Gijón

• Book ID: 102954238
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 629 KB
• Volume: 15
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/mus.880150711

✦ Synopsis

Abstract

We report the first case of McArdle's disease (muscle phosphorylase deficiency) and tophaceous gout. To examine the contribution of adenine nucleotide degradation to the disturbance of uric acid metabolism, we labeled the adenine nucleotide pool with [8‐^14^C]adenine, and measured plasma and urine purines following vigorous exercise tests. Plasma and urinary hypoxanthine and xanthine concentrations and the specific radioactivity of urinary purines increased markedly, but plasma urate levels and uric acid excretion were not substantially modified. We suggest that, in this patient, the association of McArcle's disease with gout is coincidental. © 1992 John Wiley & Sons, Inc.