MBR-PSOLA: Text-To-Speech synthesis based on an MBE re-synthesis of the segments database

A short synthesis of the C15–C21 segment

A short synthesis of the C15–C21 segment of (+)-discodermolide, based on an asymmetric approach from achiral 2-methyl-1,3-propanediol to versatile enantiopure stereotriads

✍ Kazi A. Shahid; Yong-Nan Li; Momotoshi Okazaki; Yoshihiro Shuto; Fumitaka Goto; 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 136 KB

A new approach was developed to versatile enantiopure stereotriads using chiral oxazaborolidinone-promoted asymmetric aldol reaction of a racemic aldehyde with a bromo silyl nucleophile. A short synthesis of the C 15 -C 21 segment of (+)-discodermolide was achieved by elongation of one of the stereo