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Maximum likelihood estimation via the ECM algorithm: A general framework

โœ Scribed by MENG, XIAO-LI; RUBIN, DONALD B.

Book ID
115313700
Publisher
Oxford University Press
Year
1993
Tongue
English
Weight
758 KB
Volume
80
Category
Article
ISSN
0006-3444

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## Abstract In linkage analysis, estimated recombination fractions between a disease gene and several markers are used to assign the disease gene to a a particular chromosome region. For rare diseases, locus heterogeneity leads to different recombination fractions in different families, and a set o