✦ LIBER ✦

Maturation rates and transition probabilities of cycling cells

✍ Scribed by Elhanan Sahar; Michael L. Wage; Dr. Samuel A. Latt

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 659 KB
Volume: 4
Category: Article
ISSN: 0196-4763
DOI: 10.1002/cyto.990040303

No coin nor oath required. For personal study only.

✦ Synopsis

The kinetics of cell cycling are analyzed in terms of equations incorporating a DNA synthesis rate continuously varying along S phase and a portion of G1 phase through which the cells advance in a probabilistic fashion. These equations are solved analytically for several steady state as well as nonsteady state populations of cells. Experiments are described il- lustrating how these results can be ap-plied to obtain both the rate of DNA synthesis at each point along S-phase and the probability of transition through the nondeterministic portion of G1.

📜 SIMILAR VOLUMES

Transition probability cell cycle model

Transition probability cell cycle model with product formation

✍ Scott J. Cain; Pao C. Chau 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 253 KB

A cell cycle population model based on the transition probability model of Smith and Martin (1973) has been extended to include product synthesis and export. The model handles two probable mechanisms. In the direct production model, the product is the protein. In the transcription model, the product

Transition Probability Cell Cycle Model

Transition Probability Cell Cycle Model Part I—Balanced Growth

✍ Scott J. Cain; Pao C. Chau 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 350 KB

A cell cycle model based on the concept of a transition probability first proposed by Smith & Martin has been implemented as a differential equation model. The probabilistic A-state is modeled as a lumped parameter while the deterministic B-phase is modeled as a distributed parameter, and analytical

Transition Probability Cell Cycle Model.

Transition Probability Cell Cycle Model. Part II—Nonbalanced Growth

✍ Scott J. Cain; Pao C. Chau 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 346 KB

A cell cycle model based on the transition probability model of Smith & Martin has been extended to non-balanced growth conditions in batch cultures. The model considers transition to a quiescent cell fraction, variable maturity-velocity, exogenous maintenance, and cell death. This extended model is

Rate coefficient and transition probabil

Rate coefficient and transition probability of XeO

✍ Masaaki Yamagishi 📂 Article 📅 1983 🏛 Elsevier Science 🌐 English ⚖ 321 KB

A transition probability cell cycle mode

A transition probability cell cycle model simulation of bivariate DNA/bromodeoxyuridine distributions

✍ Scott J. Cain; Pao C. Chau 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 164 KB 👁 1 views

The transition probability cell cycle model is extended to describe both cell cycle variability and incorporation of bromodeoxyuridine (BrdUrd). The model can simulate BrdUrd uptake in both pulsechase and continuous-labeling experiments. With the use of a random transition, variability due to cell c

Probability of transition into cell cycl

Probability of transition into cell cycle does not depend on growth factor concentration

✍ Ralph M. Böhmer; Lynette D. Beattie 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 420 KB 👁 1 views

When quiescent cells in monolayer culture are stimulated to proliferate with growth factor, the entry into S-phase or mitosis appears to follow first-order kinetics, with a probability to enter the cell cycle that depends on growth factor concentration (Smith and Martin, 1973). Suboptimal growth fac