𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Maturation of the human fetal brain as observed by 1H MR spectroscopy

✍ Scribed by René D. Kok; Paul P. van den Berg; Adrianus J. van den Bergh; Roel Nijland; Arend Heerschap

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
568 KB
Volume
48
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Proton MRS was used to monitor cerebral metabolite tissue levels in 35 normal fetuses during development in the gestational age range of 30–41 weeks. First, MRI in three orthogonal orientations was performed. A volume of interest (VOI) (15–43 cc) of fetal brain tissue was then selected for ^1^H MRS. For localization, two pulse sequences (stimulated echo acquisition mode (STEAM) at TE = 20 ms, and point‐resolved spectroscopy (PRESS) at TE = 135 ms) were applied. The MR spectra of the brain showed signals for inositol (Ino), choline (Cho), creatine (Cr), and N‐acetyl (NA) compounds. From 30 to 41 weeks the absolute tissue level of NA, and the ratios of NA/Cr and NA/Cho increased, whereas the ratio of Cho/Cr decreased. These changes reflect maturation of the brain. Considering the diagnostic value of proton MRS in pediatric neurology, this new approach may also be useful for characterizing pathological conditions in the fetal brain. Magn Reson Med 48:611–616, 2002. © 2002 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Non-invasive observation of acetyl-group
Non-invasive observation of acetyl-group buffering by 1H-MR spectroscopy in exercising human muscle
✍ Roland Kreis; Bruno Jung; Stan Rotman; Johannes Slotboom; Chris Boesch 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 93 KB

The observation of a previously unidentified peak in localized 1 H magnetic resonance (MR) spectra of human muscle during and after a work load is reported. Basic NMR properties of this resonance, as well as physiologic circumstances of its observation, suggest that it is due to the acetyl group of

In vivo detection of serine in the human
In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1H-MRS) at 7 Tesla
✍ Changho Choi; Ivan Dimitrov; Deborah Douglas; Chenguang Zhao; Halima Hawesa; Sub 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 349 KB 👁 1 views

## Abstract A single‐voxel proton magnetic resonance spectroscopy (^1^H‐MRS) filtering strategy for in vivo detection of serine (Ser) in human brain at 7T is proposed. Spectral difference of coupled resonances arising from different subecho times of triple refocusing at a constant total echo time (

Brain metabolite composition during earl
Brain metabolite composition during early human brain development as measured by quantitative in vivo 1H magnetic resonance spectroscopy
✍ R. Kreis; L. Hofmann; B. Kuhlmann; C. Boesch; E. Bossi; P.S. Hüppi 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 192 KB

Biochemical maturation of the brain can be studied noninvasively by (1)H magnetic resonance spectroscopy (MRS) in human infants. Detailed time courses of cerebral tissue contents are known for the most abundant metabolites only, and whether or not premature birth affects biochemical maturation of th

Measurement of N-acetylaspartylglutamate
Measurement of N-acetylaspartylglutamate in the human frontal brain by 1H-MRS at 7 T
✍ Changho Choi; Subroto Ghose; Jinsoo Uh; Aditya Patel; Ivan E. Dimitrov; Hanzhang 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 262 KB

## Abstract __N__‐Acetylaspartylglutamate in human brain has been measured with difference editing at 7 T. The CH~2~ proton resonances (∼2.5 ppm) of the aspartyl groups of __N__‐acetylaspartylglutamate and __N__‐acetylaspartate were difference edited (MEGA) using 20‐msec gaussian radiofrequency pul