Maturation-dependent repair of untreated osteochondral defects in the rabbit knee joint

✍ Scribed by Wei, Xiaochun ;Gao, Jizong ;Messner, Karola

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 946 KB
• Volume: 34
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(199701)34:1<63::aid-jbm9>3.0.co;2-l

✦ Synopsis

Repair of untreated full-thickness cartilage defects in the medial femoral knee condyle was studied in 17 young, 21 adolescent, and 19 adult rabbits. At 6 weeks, the defect was completely filled by tissue regeneration in all young and adolescent animals, but in only few of the adults (p < 0.05). The morphology of all repairs improved from fibrous tissue to hyaline-like cartilage over time (p < 0.05), but at 3 and 6 weeks, the repair tissue in young and adolescent rabbits was more cartilage-like than in the adults (p < 0.05). In addition, bonding of the repair tissue to the adjacent cartilage was better in the young and adolescent than in the adult animals (p < 0.05). At 12 weeks, subchondral bone had formed in some young and adolescent repairs, but in no case in the adults. None of the repairs showed normal cartilage appearance, but formation of hyaline-like cartilage was common at 12 weeks. Irrespective of age or observation time, the repair site showed decreased stiffness and larger strain values compared to adjacent or control cartilage (p < 0.001) with no tendency for improvement over time. Younger animals showed a faster filling of the defect and an earlier specialization of the repair tissue than adult animals, but the mechanical quality of the regenerated tissue remained inferior to normal.