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Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion

โœ Scribed by Dimitra Bourboulia; William G. Stetler-Stevenson


Book ID
113900454
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
393 KB
Volume
20
Category
Article
ISSN
1044-579X

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Degradation of the extracellular matrix (ECM) is an essential step in tumour invasion and metastasis. The matrix metalloproteinases (MMPs) each have different substrate specificities within the ECM and are important in its degradation. MMP activity is dependent on the levels of activated MMP and tis