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Matrix-metalloproteinases and their inhibitors in plasma and tumor tissue of patients with renal cell carcinoma

✍ Scribed by Michael Lein; Klaus Jung; Christian Laube; Tobias Hübner; Bjoern Winkelmann; Carsten Stephan; Steffen Hauptmann; Birgit Rudolph; Dietmar Schnorr; Stefan A. Loening

Publisher
John Wiley and Sons
Year
2000
Tongue
French
Weight
70 KB
Volume
85
Category
Article
ISSN
0020-7136

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✦ Synopsis

Matrix-metalloproteinases (MMPs) are associated with invasive and metastatic behavior of several human malignant tumors. We have determined MMP-2 and MMP-9 and tissue inhibitors of MMPs (TIMP-1 and TIMP-2) in blood plasma and in renal tissue samples of patients with renal cell carcinoma (RCC) from cancerous and non-cancerous parts of the same kidney. In tumor tissue, MMP-9 and TIMP-1 were significantly higher than in normal counterparts. MMP-2 was not different between tumor tissue and normal counterparts. TIMP-2 values could not be measured. In plasma, MMP-9 concentrations were significantly higher in RCC patients than in healthy controls, MMP-2 and TIMP-2 concentrations were higher in healthy controls and TIMP-1 concentrations were not different. Int.

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