Matrix metalloproteinases 2 and 9 (gelatinases A and B) expression in malignant mesothelioma and benign pleura
✍ Scribed by Edwards, J G; McLaren, J; Jones, J L; Waller, D A; O'Byrne, K J
- Book ID
- 109997558
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 145 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0007-0920
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Matrix metalloproteinases (MMP) types 2 and 9 (also known as gelatinase A and B) are thought to be causally involved in cancer invasion and metastasis. In normal as well as in malignant tissue, both these MMPs occur in multiple forms such as inactive precursors, active enzymes and enzyme-inhibitor c
## Abstract To investigate the relevance of gelatinase‐B (matrix metalloproteinase 9, MMP‐9) in gouty arthritis (GA), we tested the occurrence of MMP‐9 in GA patients and cell culture system. Gelatinolytic activity in the synovial fluid (SF) of patients with different kinds of arthritis was assesse
## Abstract ## Objective Expression of matrix metalloproteinase 9 (MMP‐9) is up‐regulated in osteoarthritis (OA) and usually presents as multiple bands when synovial fluid (SF) from OA patients is analyzed by zymography. Among these bands is an ∼125–130–kd band for high molecular weight (HMW) gela