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Matrix metalloproteinase-9 and non-amyloidogenic pathway of amyloid precursor protein processing

✍ Scribed by Mikhail A. Filippov; Alexander Dityatev


Book ID
115270782
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
141 KB
Volume
121
Category
Article
ISSN
0022-3042

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We have studied the influence of the extracellular matrix (ECM) on the amount of beta-amyloid precursor protein (APP) and C-terminal amyloid-bearing fragments in 313 fibroblasts. After incubation with ECM components, the cellular APP content of 3T3 cells changed. Besides, different substrata includi