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Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor α2 in vivo

✍ Scribed by Chen, Weiguo; Tabata, Yasuhiro; Gibson, Aaron M.; Daines, Michael O.; Warrier, Manoj R.; Wills-Karp, Marsha; Khurana Hershey, Gurjit K.

Book ID: 119280873
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 549 KB
Volume: 122
Category: Article
ISSN: 1097-6825
DOI: 10.1016/j.jaci.2008.06.022

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## Abstract Matrix metalloproteinase‐1 (MMP‐1, collagenase‐1) plays a pivotal role in the process of joint destruction in degenerative joint diseases. We have examined the regulation of MMP‐1 production in human chondrocytic HCS‐2/8 cells stimulated by tumor necrosis factor‐α (TNF‐α). In response t