Matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) in preoperative serum as independent prognostic markers in patients with colorectal cancer
✍ Scribed by Vesna V. Dragutinović; Nevena V. Radonjić; Nataša D. Petronijević; Svetislav B. Tatić; Ivan B. Dimitrijević; Nebojša S. Radovanović; Zoran V. Krivokapić
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 264 KB
- Volume
- 355
- Category
- Article
- ISSN
- 0300-8177
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## Abstract ## Background. Factors that represent the potential for invasion and metastasis, such as matrix metalloproteinases (MMPs), could predict prognosis of cancer. Therefore, the authors studied plasma and tissue levels of MMP‐2 and MMP‐9 in oral cancer, the leading malignancy in India. ##
Matrix metalloproteinases, and notably the gelatinases MMP-2 and MMP-9, have important roles in tumour invasion, metastasis and angiogenesis. Our study investigates the distribution of MMP-2 and MMP-9 in colorectal cancer, the correlation with plasma levels, changes following surgical resection and