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Matrix Metalloproteinase 11 (MMP-11; Stromelysin-3) and Synthetic Inhibitors

✍ Scribed by Magdalini Matziari; Vincent Dive; Athanasios Yiotakis

Publisher
John Wiley and Sons
Year
2007
Weight
11 KB
Volume
38
Category
Article
ISSN
0931-7597

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Matrix metalloproteinase 11 (MMP-11; str
Matrix metalloproteinase 11 (MMP-11; stromelysin-3) and synthetic inhibitors
✍ Magdalini Matziari; Vincent Dive; Athanasios Yiotakis 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 457 KB

## Abstract Matrix metalloproteinase (MMP)‐11, or Stromelysin 3, is a particular member of MMP family, a group of zinc‐dependent endopeptidases involved in matrix degradation and tissue remodeling. Despite intense efforts since its first characterization 15 years ago, its role and target substrates

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## Abstract MMP11 expression is a poor prognosis factor in human carcinomas. Although it has been shown to favor primary tumor development, its role in metastatic processes remains unclear. We studied the hematogenous metastatic activity of C26 mouse colon cancer cells injected into the tail vain o