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Matrix interference in ligand-binding assays: challenge or solution?

✍ Scribed by DeSilva, Binodh; Garofolo, Fabio


Book ID
126875119
Publisher
Future Science
Year
2014
Tongue
English
Weight
667 KB
Volume
6
Category
Article
ISSN
1757-6180

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## BACKGROUND. Historically, estrogen receptor (ER) determinations have been made by the ligand-binding assay of tumor homogenates, primarily by the dextrancoated charcoal method (DCC). Irnrnunocytochernical assays (ICA) for ER are more recent and have been executed mostly on frozen sections with t