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Matrix changes induced by transglutaminase 2 lead to inhibition of angiogenesis and tumor growth

✍ Scribed by Jones, R A; Kotsakis, P; Johnson, T S; Chau, D Y S; Ali, S; Melino, G; Griffin, M

Book ID
110017118
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
544 KB
Volume
13
Category
Article
ISSN
1350-9047

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## Abstract NK4 exhibits two distinct biological actions: antagonistic inhibition of hepatocyte growth factor (HGF) through binding to the Met/HGF receptor, and antiangiogenic action through binding to perlecan. Here, the anti‐tumor effect of NK4 on malignant pleural mesothelioma was investigated.