The metalloproteinases, a multigene family of metal-requiring enzymes, have been suggested t o play a role in tumor invasion and metastasis. Previously, we demonstrated that human primary prostate tumors express higher levels of matrilysin and gelatinase A mRNA than normal prostate does. In the stud
Matrilysin Expression in the Involuting Rat Ventral Prostate
โ Scribed by Dr. William C. Powell; Frederick E. Domann Jr.; Joan M. Mitchen; Lynn M. Matrisian; Raymond B. Nagle; G. Tim Bowden
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 923 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0270-4137
No coin nor oath required. For personal study only.
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## BACKGROUND. In an effort to identify biomarker(s) for prostatic cancer (PCa), we analyzed the changes of secretory proteins in the ventral prostate (VP) of Noble rats at early stages of carcinogenesis. METHODS. Ventral prostates were removed from both control (n = 36) and experimental (n = 88) r
## Abstract We have hypothesized that epithelial growth, branching, and canalization in the rodent ventral prostate (VP) would require matrix remodeling, and hence matrix metalloproteinase (MMP) activity. Therefore, the aim of this study was to evaluate the impact of blocking MMPโ2, using whole org