Mathematical simulation of complex chromatographic systems: a simulation model of reversed-phase liquid chromatography of metal chelates

✍ Scribed by A.R. Timerbaev; I.G. Tsoi; O.M. Petrukhin

• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 856 KB
• Volume: 269
• Category: Article
• ISSN: 0003-2670
• DOI: 10.1016/0003-2670(92)85407-w

✦ Synopsis

An eqmhbrmm model for descrlbmg the reversed-phase hqmd chromatographlc behavlour of metal chelates has been developed Thus model takes account of possible chemical reactlons accompanymg the chromatographrc process for metal chelates, I e , dasoctatlon, hydrolysis, adduct formation, etc The mam expertmental parameters affecting on the eqmbbnum concentration of a metal chelate m a mobile phase (stabthty and amount of chelate, nature and concentration of an organic modifier, acid@, concentration of a chelating reagent, etc 1 were analysed The basic model conclusions were confirmed experunentally on an example of metal dlthlocarbamates and dlthlophosphates Recommendations on selectmg the optimum chelates for metal analysis and condltlons for chelate stabdlzatlon and separation by reversed-phase hqmd chromatography were elaborated Keywords Liquid chromatography, Optmuzatlon methods, Mathematical slmulatlon, Metal chelates, Slmulatlon