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Mathematical modeling confirms the length-dependency of telomere shortening

โœ Scribed by Jorn op den Buijs; Paul P.J. van den Bosch; Mark W.J.M. Musters; Natal A.W. van Riel

Book ID
113775667
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
169 KB
Volume
125
Category
Article
ISSN
0047-6374

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hortening of telomeres is one of the supposed mechanisms of cellular aging and death. An important question related to this so-called "end-replication" hypothesis is whether it can explain in quantitative detail the dynamic of cell sensescence in vitro and in vivo. A natural way to answer this quest