Mathematical model to simulate the cellular dynamics of infection with human herpesvirus-6 in EBV-negative infectious mononucleosis
✍ Scribed by Guanyu Wang; Gerhard R.F. Krueger; L. Maximilian Buja
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 130 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
Abstract
Acute infection with human herpesvirus‐6 induces physiological cell proliferation in persons without major immune deficiency. It thus can serve as a parameter to validate a mathematical model designed to simulate cell proliferation under physiological and pathological conditions. Such a mathematical model is presented to simulate various cell changes of the T‐cell immune system during the course of HHV‐6 infection. Model development follows several steps, beginning with a basic model containing physiological T‐cell pools to the introduction of infectious stimuli in the final model. A search algorithm designed to optimize the system parameters, as well as initial variables of the model, is presented. The results of simulation runs for acute HHV‐6 infection of the final computational model correspond well to the data, as documented in human patients; they suggest that the computational model presented for the simulation of T‐cell levels in a given viral infection may well serve as a tool for similar studies of other viral infections, including those that lead to cellular aplasia or neoplasia. J. Med. Virol. 71:569–577, 2003. © 2003 Wiley‐Liss, Inc.