Mathematical model for frequency modulation in the respiratory network

✍ Scribed by Natalia Toporikova; Robert Butera

• Book ID: 104492778
• Publisher: BioMed Central
• Year: 2011
• Tongue: English
• Weight: 341 KB
• Volume: 12
• Category: Article
• ISSN: 1471-2202
• DOI: 10.1186/1471-2202-12-s1-p25

✦ Synopsis

Figure 1 Inspiratory frequency modulation of pBC by excitatory neurotransmitters, which act on G q -coupled receptor. [NT] represents neurotransmitter concentration. (A-C) Example of raster plots for three different neurotransmitter concentrations. (A) Rhythmic activity is absent for low concentration of neurotransmitter ([NT]=0.7 µM). (B) Increase in neuromodulatory tone ([NT]=1 µM) results in a slow bursting rhythm. (C) Elevation of neurotransmitter concentration ([NT]=1.3µM) increases the burst frequency in pBC. (D) Burst frequency of pBC neurons as a function of neurotransmitter concentration. The vertical bars represent the standard error from an average of 10 network simulations.