Mathematical model for empirically optimizing large scale production of soluble protein domains
β Scribed by Eisuke Chikayama; Atsushi Kurotani; Takanori Tanaka; Takashi Yabuki; Satoshi Miyazaki; Shigeyuki Yokoyama; Yutaka Kuroda
- Book ID
- 114999101
- Publisher
- BioMed Central
- Year
- 2010
- Tongue
- English
- Weight
- 817 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1471-2105
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A method for modeling largescale rearrangements of protein domains connected by a single-or a double-stranded linker is proposed. Multidomain proteins may undergo substantial domain displacements, while their intradomain structure remains essentially unchanged. The method allows automatic identifica
## Abstract Energy minimization plays an important role in structure determination and analysis of proteins, peptides, and other organic molecules; therefore, development of efficient minimization algorithms is important. Recently, Morales and Nocedal developed hybrid methods for largeβscale uncons