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Mathematical and experimental analysis of localization of anti-tumour antibody–enzyme conjugates

✍ Scribed by Jackson, T L; Lubkin, S R; Siemers, N O; Kerr, D E; Senter, P D; Murray, J D

Book ID
110002379
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
112 KB
Volume
80
Category
Article
ISSN
0007-0920

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## Abstract As an approach to developing more specific anti‐tumour therapeutic agents, daunomycin has been covalently linked to the human tumour localizing, murine monoclonal antibody 79IT/36. Four procedures for coupling drug to antibody were investigated. The sugar amino group of daunomycin was m