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Maternal serum screening for Down syndrome in pregnancies conceived by intra-uterine insemination

✍ Scribed by Te-Yao Hsu; Chia-Yu Ou; Jenn-Jeih Hsu; Fu-Tsai Kung; Shiun-Young Chang; Yung-Kuei Soong

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 54 KB
Volume: 19
Category: Article
ISSN: 0197-3851
DOI: 10.1002/(sici)1097-0223(199911)19:11<1012::aid-pd688>3.0.co;2-0

No coin nor oath required. For personal study only.

✦ Synopsis

The purpose of our study was to assess the influence of intra-uterine insemination (IUI) on the results of maternal serum Down syndrome screening. 43 women with IUI pregnancies and 4507 healthy women who conceived were studied. Ovulation in IUI pregnancies was induced by clomiphene and/or human menopausal gonadotrophin (hMG). Maternal serum levels of free -human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP) were measured for Down syndrome screening. It was considered screen-positive when the risk of Down syndrome was 1 in 270 or greater in the second trimester. The value of maternal serum AFP was significantly lower in the IUI group (median=0.760 MoM) than in the control group (median=1.050 MoM). However, the value of free -hCG was not significantly different between the two groups. The positive rate of maternal serum Down syndrome in IUI pregnancies was similar to that of the control group. Our results indicate that IUI pregnancy may be associated with a lower level of AFP, although the mechanism for this difference remains unknown.

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