𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Maternal serum homocysteine and risk for neural tube defects in a Texas-Mexico border population

✍ Scribed by Marilyn Felkner; Lucina Suarez; Mark A. Canfield; Jean D. Brender; Qin Sun

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
100 KB
Volume
85
Category
Article
ISSN
1542-0752

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

BACKGROUND:

To better understand the neural tube defect (NTD) causal pathway, the authors measured homocysteine, an indicator of tissue micronutrient deficiencies. The authors examined independent and joint associations of serum homocysteine, B~12,~ and folate and red blood cell (RBC) folate with NTD‐affected pregnancies.

METHODS:

Case women in this population‐based study had NTD‐affected pregnancies and resided and delivered in one of the 14 Texas‐Mexico border counties from 1995 through 2000. Control women were study area residents delivering normal live births during the same period. The authors measured homocysteine levels using tandem mass spectroscopy; competitive binding was used for other biomarkers.

RESULTS:

Homocysteine testing was done on 103 cases and 139 controls. Odds ratios (ORs) were increased in all upper homocysteine quintiles compared to the lowest quintile (1.7, 1.3, 2.8, 2.4). Women with high homocysteine values had increased ORs regardless of high versus low levels for B~12~ (OR = 3.5, 4.8, respectively) or RBC folate (OR = 2.9, 3.5, respectively).

CONCLUSIONS:

High serum homocysteine levels are associated with NTD‐affected pregnancies. Moreover, high homocysteine levels have a detrimental effect on NTD‐risk even when serum B~12~ or RBC folate levels are high. Excess homocysteine might play an independent role in the development of NTDs. Birth Defects Research (Part A), 2009. © 2009 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

The effect of fever, febrile illnesses,
The effect of fever, febrile illnesses, and heat exposures on the risk of neural tube defects in a Texas-Mexico border population
✍ Lucina Suarez; Marilyn Felkner; Kate Hendricks 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 77 KB 👁 1 views

## Abstract ## BACKGROUND Hyperthermia produces neural tube defects (NTDs) in a variety of animal species. Elevated maternal body temperatures may also place the developing human embryo at risk. We examined the relation between maternal hyperthermia and the development of NTDs in a high‐risk Mexic

Reduced folate carrier gene is a risk fa
Reduced folate carrier gene is a risk factor for neural tube defects in a Chinese population
✍ Lijun Pei; Huiping Zhu; Aiguo Ren; Zhiwen Li; Ling Hao; Richard H. Finnell; Zhu 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 75 KB 👁 1 views

## Abstract ## BACKGROUND There is a considerable body of data demonstrating that periconceptional supplementation of folic acid can prevent a significant proportion of neural tube defects (NTDs). At present, the mechanism by which folic acid exerts its beneficial effect remains unknown. Folate tr

Maternal prepregnancy body mass index an
Maternal prepregnancy body mass index and risk of neural tube defects: A population-based case–control study in Shanxi province, China
✍ Zhiwen Li; Jianmeng Liu; Rongwei Ye; Le Zhang; Lijun Pei; Xiaoying Zheng; Aiguo 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 82 KB 👁 2 views

## Abstract ## BACKGROUND: Many studies from the Western world have indicated that maternal obesity is associated with an increased risk of neural tube defects (NTDs). However, few reports have been available on this association from Asian populations. Our aim was to examine the relationship betwe