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Maternal serum alpha-fetoprotein in fetal anal atresia and other gastro-intestinal obstructions

✍ Scribed by M. Van Rijn; G. C. M. L. Christaens; A. M. Hagenaars; G. H. A. Visser

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 180 KB
Volume: 18
Category: Article
ISSN: 0197-3851
DOI: 10.1002/(sici)1097-0223(199809)18:9<914::aid-pd376>3.0.co;2-n

No coin nor oath required. For personal study only.

✦ Synopsis

The fetal gastro-intestinal (GI) tract contributes to alpha-fetoprotein (AFP) levels in amniotic fluid and hence to those in maternal serum (MS). This study retrospectively analysed results of second trimester MSAFP screening in cases of fetal GI tract obstruction. 18 cases of fetal GI obstruction were diagnosed amongst 17 036 women who underwent MSAFP screening between 1979 and 1997: seven had oesophageal atresia, four had duodenal atresia, six had anal atresia, and one had both anal and oesophageal atresia. MSAFP in pregnancies of a fetus with anal atresia was significantly lower than the population median. MSAFP in cases of fetal oesophageal or duodenal atresia was low but these differences did not reach significance. 1998 John Wiley & Sons, Ltd.

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