๐”– Bobbio Scriptorium
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Maternal nicotine exposure: reponse of type II pneumocytes of neonatal rat pups.

โœ Scribed by G.S. Maritz; R.-A. Thomas

Book ID
102966153
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
994 KB
Volume
19
Category
Article
ISSN
1065-6995

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โœฆ Synopsis

The influence of maternal nicotine exposure during pregnancy and lactation on the Type II cells of lung tissue of one day old neonatal rat pups was investigated. The results clearly show that maternal nicotine exposure resulted in an increase in the type II cell count in the lungs of the offspring. In addition the lamellar body content of the type II cells of the nicotine exposed rat pups were significantly ((P<0.01)) higher than that of the control animals. The type II cell mitochondria of lung tissue of nicotine exposed rat pups were swollen and no microvilli occurred on the alveolar surface. This clearly illustrates that nicotine interfered with type II cell integrity of tlte neonatal lung and may subsequently interfere with the normal development of the alveolar region of the lung.

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## Abstract Nitrogen dioxide (NO~2~) is a wellโ€known environmental air toxin, produced from a variety of sources, including cigarette smoke. Because of the growing knowledge of the harmful effects of passive smoking on children, we decided to study the effect of NO~2~ exposure on the release of sur