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Maternal epilepsy and birth defects: A case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC)

✍ Scribed by R. Bertollini; P. Mastroiacovo; G. Segni

Publisher: Springer
Year: 1985
Tongue: English
Weight: 516 KB
Volume: 1
Category: Article
ISSN: 0393-2990
DOI: 10.1007/bf00162315

No coin nor oath required. For personal study only.

✦ Synopsis

Birth d e f e c t s -Valproic acid -Spina b i f i d a -Anticonvulsant drugs.

A case control study on the a s s o c i a t i 0 n b e t w e e n maternal epilepsy, anticonvulsants use during pregnancy and birth defectS' ~,as carried out in the Italian Multicentric Registry of Birth ~Defeets '(IPIMC).

In the period 1980-1983, 7,607 malformed babies out of 439,717 total births (still+live) were registered. Fourtyone malformed babies with maternal epilepsy were identified (5.39×1,000). The overall relative risk of having a malformed baby among pregnant epileptic .women was 1.87.

Spina Bifida, Congenital Heart Defects, Clefts, Diaphragmat,ic Hernia and Trisomy ,18 were more frequent than expected among babies with maternal epilepsy.

The different therapeutic regimens were also tested to identify the possible independent teratogenic effect of anticonvulsants. A statistically significant association between Spina Bifida and Valproic Acid (odds ratio 22.7; Fisher p value = 0.0364) was observed: no other anticonvulsant tested showed any association wit,h any type of malformation.

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