Maternal effect on micronucleus induction in MS/Ae mice

✍ Scribed by Shizuyo Sutou; Seiji Sato

• Book ID: 102189885
• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 390 KB
• Volume: 15
• Category: Article
• ISSN: 0893-6692
• DOI: 10.1002/em.2850150302

✦ Synopsis

MSIAe mice, which are mutagen-sensitive in both the dominant lethal test and micronucleus test, and CD-1 mice, which are the parental strain of MSIAe, were mated in all four possible combinations. Both male and female offspring were subjected to the micronucleus test using mitomycin C (MMC), colchicine (Col), and 6mercaptopurine (6-MP). Col showed equivocal results. However, MMC and 6-MP showed differential responses in that both male and female offspring from CD-1 dams had lower incidences of micronucleated polychromatic erythrocytes than those from MS/Ae dams regardless of sire strain. In addition, body weights of offspring from MSIAe dams were lower than those from CD-1 dams regardless of sire strain. Numbers of offspring from MSIAe dams tended to be smaller than those from CD dams. These results suggest that the traits of MS/Ae mice are associated more with maternal factors than with paternal ones.