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Maternal deprivation of neonatal rats produces enduring changes in dopamine function

✍ Scribed by F.S. Hall; L.S. Wilkinson; T. Humby; T.W. Robbins

Book ID
101268683
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
159 KB
Volume
32
Category
Article
ISSN
0887-4476

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✦ Synopsis

Isolation-rearing of weanling rats produces a syndrome of behavioral and neurochemical effects that are indicative of enhanced ventrostriatal dopamine function observed in adulthood. By contrast, maternal deprivation of neonatal rats decreases behavioral responses to dopamine agonists when tested in adults, which may indicate the opposite situation. However, in the present study it is reported that in vivo microdialysis of the nucleus accumbens (NAC) revealed enhanced release of dopamine (DA) in response to both d-amphetamine and high KΟ© perfusate in maternally deprived subjects. Thus, behavioral responses to d-amphetamine are diminished in maternally deprived rats despite apparent increases in presynaptic dopaminergic function in the NAC.

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