Maternal cell-mediated cytolysis of CMV-infected fetal cells and the outcome of pregnancy in the guinea pig

✍ Scribed by C. J. Harrison; M. G. Myers

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 629 KB
• Volume: 27
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.1890270114

✦ Synopsis

Cytolytic recognition of CMV-infected syngeneic fetal guinea pig cells by maternal peripheral blood mononuclear cells (PBMC) was suppressed late in pregnancies of uninfected guinea pig breeders with < 25% conceptus loss. A small subset of less successful uninfected pregnancies with 2 50% fetal wastage exhibited only partial suppression of cytolytic activity against CMV-infected fetal cells. Primary CMV infection of dams extending into early pregnancy induced augmented cytolysis of CMV-infected fetal cells, but not MA104 NK cell targets, throughout gestation and resulted in 70% loss of conceptus. Decreased suppression of cytolytic activity against CMV-infected fetal cells in uninfected pregnancy was also associated with runting of newborn pups, which was not as severe as that observed in congenitally CMV-exposed or CMV-infected pups. Congenitally infected pups were affected more than their exposed but uninfected litter mates. Lack of suppression of cytolysis of CMVinfected syngeneic fetal cells, whether spontaneous or CMV-infection-induced,appears to be associated with poor pregnancy outcome.