✦ LIBER ✦

Maternal antibody and respiratory syncytial virus infection in infancy

✍ Scribed by Dr. Marie M. Ogilvie; A. Santhire Vathenen; Martin Radford; Janet Codd; Sheila Key

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 549 KB
Volume: 7
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890070403

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

One hundred newborn infants were studied prospectively for 1 year for evidence of infection with respiratory syncytial virus (RSV). The indirect membrane fluorescence technique was used to determine specific antibody in sera. Infection was shown in 29 cases. In 31 infants exposed to an RSV epidemic season, there was no evidence of infection. Maternal antenatal sera were also tested, and a wide range of IgG antibody to RSV was found. Mean titre of maternal IgG antibody to RSV was significantly higher (P < 0.001) in those mothers whose babies remained uninfected than in those whose babies had proved RSV infection before 6 months of age. Babies born to mothers with high levels of IgG antibody to respiratory syncytial virus were protected against infection with this virus during the first months of life when the risk of severe disease was greatest.

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